Deadly fungal infection acquired during surgery in Mexico led to death and brainstem, blood supply injuries: Study

A life-threatening mold infection known as health care-associated Fusarium solani meningitis can be associated with a delayed, but devastating, injury to the brainstem and its blood supply among those infected, according to physicians from UTHealth Houston.

A report, led by first author Nora Strong, MD, and senior author Luis Ostrosky-Zeichner, MD, was published in the New England Journal of Medicine. Strong is a second-year postdoctoral fellow in infectious diseases with McGovern Medical School at UTHealth Houston, and Ostrosky is professor of medicine and epidemiology, division director of infection diseases, and Memorial Hermann Chair at the medical school.

In the report, the physicians reported their own experience and analyzed data from the clinical presentation, disease course, and management of 13 hospitalized patients in multiple centers.

Between Jan. 1, 2023, and May 13, 2023, an outbreak of Fusarium solani meningitis took place at two clinics in Matamoros, Tamaulipas, Mexico, among patients with otherwise healthy immune systems who underwent surgical procedures involving epidural anesthesia. On May 17, 2023, the Centers for Disease Control and Prevention released a Health Alert Network Health Advisory about the incident.

“The outbreak of this severe mold infection affected primarily young, otherwise healthy people as result of medical tourism,” Strong said. “Patients from Mexico and the U.S. experienced severe, and ultimately mortal, neurologic and vascular injuries as a result of the infection.”

Physicians identified 13 patients with fungal meningitis who had undergone procedures involving epidural anesthesia at one of the two identified medical clinics in Mexico. Although the infection typically affects severely immunocompromised patients, Strong said the cases demonstrate that direct inoculation of Fusarium species into the cerebrospinal fluid can cause severe meningitis in otherwise healthy patients, which is tragically associated with an extremely high mortality rate.

“All 13 patients featured involvement of the brainstem with injury to the basilar and vertebral arteries, which were typically insidious at presentation but progressed,” Strong said. “Over time, multiple patients experienced the narrowing of important blood vessels in their brains, leading to stroke or severe hemorrhages that eventually led to death in many of the patients.”

Nine of the 13 patients died due to vessel injury. Of the four surviving patients, three remain on Fosmanogepix monotherapy, an experimental treatment for invasive mold infections, and one is no longer receiving the antifungal medication. One patient who remains on therapy experienced abulia—a state of diminished motivation—after subarachnoid hemorrhage. The other three patients have no cognitive, sensory, or motor deficits from the infection.

More information:
Nora Strong et al, Neurovascular Complications of Iatrogenic Fusarium solani Meningitis, New England Journal of Medicine (2024). DOI: 10.1056/NEJMoa2308192