Space travel is dangerous. Could genetic testing and gene editing make it safer?

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Recently, global news has been pretty bleak. So this week, I’ve decided to focus my thoughts beyond Earth’s stratosphere and well into space. A couple of weeks ago, SpaceX launched four private astronauts into orbit, where they performed the first ever spacewalk undertaken by private citizens (as opposed to astronauts trained by national agencies).

The company has more ambitious plans for space travel, and it’s not alone. Elon Musk, the founder of SpaceX, claimed on Sunday that he would launch uncrewed missions to Mars within two years, and crewed missions four years after that if the uncrewed missions were successful. (Other SpaceX timelines for reaching the Red Planet haven’t panned out.) NASA refers to Mars as its “​​horizon goal for human exploration.” China previously announced plans for a human mission as early as 2033 and recently moved up its timeline for an uncrewed sample return mission by two years. And the UAE has a 100-year plan to construct a habitable community on Mars by 2117.

None of this will be straightforward. Long-distance space travel can wreak havoc on human health. There’s radiation and microgravity to contend with, as well as the psychological toll of isolation and confinement. Research on identical twin astronauts has also revealed a slew of genetic changes that happen when a person spends a year in space.

That’s why some bioethicists are exploring the idea of radical treatments for future astronauts. Once we’ve figured out all the health impacts of space travel, they argue, we should edit the genomes of astronauts ahead of launch to offer them the best protection. Some have even suggested this might result in the creation of an all-new species: Homo spatialis. If this is starting to sound a bit like sci-fi, that’s because—for now, at least—it is. But there are biotechnologies we can use to help space travelers now, too.

Space travel is risky. When it comes down to it, a space launch essentially involves strapping humans into a capsule and exploding a bomb beneath them, says Paul Root Wolpe, who served as NASA’s senior bioethicist for 15 years.

Once you’re in space, you’re subject to far higher levels of radiation than you’d encounter on Earth. Too much radiation can increase a person’s risk of cancer and neurological disorders. It can also harm body tissues, resulting in cataracts or digestive diseases, for example. That’s why agencies like the US Department of Labor’s Occupational Safety and Health Administration set limits on radiation exposure. (NASA also sets limits on the amount of radiation astronauts can be exposed to.)

Then there’s microgravity. Our bodies have adapted to Earth’s gravity. Without that gravitational pull, strange things can happen. For one thing, internal fluids can start to pool at the top of the body. Muscles don’t need to work as hard when there’s no gravity, and astronauts tend to experience loss of muscle mass as well as bone.

Five years ago, scientists working with NASA published the results of a groundbreaking study comparing two identical twins—one of whom spent a year in space while the other remained on Earth. The twins, Mark and Scott Kelly, were both trained astronauts. And because they have the same set of genes, researchers were able to compare them to assess the impact of long-term space travel on how genes work.

The researchers found that both twins experienced some changes to the way their genes worked over that period, but they changed in different ways. Some of the effects in the space-faring brother lasted for more than six months. These changes are thought to be a response to the stress of space travel and perhaps a reaction to the DNA damage caused by space radiation.

Space travel comes with other risks, including weight loss, permanent eye damage caused by what is known as “spaceflight-associated neuro-ocular syndrome,” and psychological distress as a result of being far from friends and loved ones.

And if all that weren’t enough, injuries are also common on space missions, says Wolpe, who is now founding director of the Center for Peace Building and Conflict Transformation at Emory University. Tools and equipment can float around, knocking into people. Bungee cords snap. “Astronauts are supposed to wear safety goggles at all times, but they didn’t,” says Wolpe. “The injury list is lengthy … it’s really surprising how many injuries were [sustained] by astronauts on the space station.”

Commercial space travel brings a new set of dangers. Until very recently, the only people who traveled to space went through rigorous health tests and training programs overseen by national agencies. That isn’t the case for private space travel, where the rules are determined by the individual company, says Wolpe.

Astronauts are screened for common conditions like high blood pressure and diabetes. Space tourists might not be. We’re still learning the basics when it comes to the impact of space travel on health. We have no idea how it might affect a person who has various disorders and takes multiple medications.

Could gene editing protect astronauts from these potential problems? People who have adapted to high altitudes on Earth have genetic factors that allow them to thrive in low-oxygen environments—what if we could confer these factors to astronauts? And while we’re at it, why not throw in some more genetic changes—ones that might protect them from bone or muscle loss, for example?

Here’s where we get into Homo spatialis territory—the idea of a new species better suited to a life in space, or on a planet other than Earth. For the time being, this approach is not an option—there are currently no gene therapies that have been designed for people undertaking space travel. But one day “it might be in the best interests of the astronauts to undergo some genetic intervention, like gene editing, to safeguard them,” says Rosario Isasi, a bioethicist at the University of Miami. “It might be more than a duty, but a condition for an astronaut going on these missions.”

Wolpe is not keen on the idea. “There is some integrity to being human, and to the human body, that should not be breached,” he says. “These kinds of modifications are going to … end up with a number of disasters.” Isasi also hopes that advances in precision medicine, which will make possible bespoke treatments for individuals, might sidestep the need for genetic modifications.

In the meantime, genetic testing could be helpful for both astronauts and space tourists, says Wolpe. Some body tissues are more vulnerable to radiation damage, including the thyroid gland. Genetic tests that reveal a person’s risk of thyroid cancer might be useful for those considering space travel, he says.

Whether people are going into space as tourists, employees, scientists, or research subjects, figuring out how to send them safely is vitally important. After all, space tourism is nothing like regular tourism. “You’re putting [people] in a situation the human body was never designed to be in,” says Wolpe.

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The International Space Station is getting old, and there are plans to destroy it by 2030. Now NASA is partnering with private companies to develop new commercial space stations for research, manufacturing, and tourism, reports David W. Brown.

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